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Consortium publications

Examining the Utility of the Mammalian Methylation Array for Pan-Mammalian Analysis of Monozygotic Twinning. 

van Dongen J, Breeze CE, Twinning Genetics Consortium. Epigenomes. 2024; 8(4):37. https://doi.org/10.3390/epigenomes8040037

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Hamdi Mbarek, Scott D Gordon, David L Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J Beck, Jouke-Jan Hottenga, René Pool, Conor V Dolan, Ky’Era V Actkins, Zachary F Gerring, Jenny Van Dongen, Erik A Ehli, William G Iacono, Matt Mcgue, Daniel I Chasman, C Scott Gallagher, Samantha L P Schilit, Cynthia C Morton, Guillaume Paré, Gonneke Willemsen, David C Whiteman, Catherine M Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K E Magnusson, Nancy L Pedersen, Pirro Hysi, Massimo Mangino, Timothy D Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W Penninnx, Adrian I Campos, Ken K Ong, John R B Perry, Cornelis B Lambalk, Jaakko Kaprio, Ísleifur Ólafsson, Karine Duroure, Céline Revenu, Miguel E Rentería, Loic Yengo, Lea Davis, Eske M Derks, Sarah E Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W Montgomery, Dorret I Boomsma, Nicholas G Martin, Human Reproduction, Volume 39, Issue 1, 2024, Pages 240–257, https://doi.org/10.1093/humrep/dead247

Identical twins carry a persistent epigenetic signature of early genome programming.

van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, Moffitt TE, Hagenbeek FA, van Beijsterveldt CEM, Jan Hottenga J, Tsai PC; BIOS Consortium; Genetics of DNA Methylation Consortium, Min JL, Hemani G, Ehli EA, Paul F, Stern CD, Heijmans BT, Slagboom PE, Daxinger L, van der Maarel SM, de Geus EJC, Willemsen G, Montgomery GW, Reversade B, Ollikainen M, Kaprio J, Spector TD, Bell JT, Mill J, Caspi A, Martin NG, Boomsma DI.Nat Commun. 2021 Sep 28;12(1):5618. doi: 10.1038/s41467-021-25583-7.

Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight. Beck JJ, Pool R, van de Weijer M, Chen X, Krapohl E, Gordon SD, Nygaard M, Debrabant B, Palviainen T, van der Zee MD, Baselmans B, Finnicum CT, Yi L, Lundström S, van Beijsterveldt T, Christiansen L, Heikkilä K, Kittelsrud J, Loukola A, Ollikainen M, Christensen K, Martin NG, Plomin R, Nivard M, Bartels M, Dolan C, Willemsen G, de Geus E, Almqvist C, Magnusson PKE, Mbarek H, Ehli EA, Boomsma DI, Hottenga JJ.Hum Mol Genet. 2021 Sep 15;30(19):1894-1905. doi: 10.1093/hmg/ddab121

Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning.

van Dongen J, Gordon SD, Odintsova VV, McRae AF, Robinson WP, Hall JG, Boomsma DI, Martin NG.Twin Res Hum Genet. 2021 Jun;24(3):155-159. doi: 10.1017/thg.2021.25.

Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them.

Mbarek H, Dolan CV, Boomsma DI. Twin Res Hum Genet. 2016 Oct;19(5):418-21. doi: 10.1017/thg.2016.53. PMID: 2740642

Biological insights into multiple birth: genetic findings from UK Biobank.

Mbarek H, van de Weijer MP, van der Zee MD, Ip HF, Beck JJ, Abdellaoui A, Ehli EA, Davies GE, Baselmans BML, Nivard MG, Bartels M, de Geus EJ, Boomsma DI.Eur J Hum Genet. 2019 Jun;27(6):970-979. doi: 10.1038/s41431-019-0355-z.

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

Mbarek H, Steinberg S, Nyholt DR, Gordon SD, Miller MB, McRae AF, Hottenga JJ, Day FR, Willemsen G, de Geus EJ, Davies GE, Martin HC, Penninx BW, Jansen R, McAloney K, Vink JM, Kaprio J, Plomin R, Spector TD, Magnusson PK, Reversade B, Harris RA, Aagaard K, Kristjansson RP, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Iacono WG, Lambalk CB, Montgomery GW, McGue M, Ong KK, Perry JR, Martin NG, Stefánsson H, Stefánsson K, Boomsma DI. Am J Hum Genet. 2016 May 5;98(5):898-908. doi: 10.1016/j.ajhg.2016.03.008. PMID: 27132594